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Article

Identifying Conserved Regions in HIV-1 Proteins by Entropy Analysis of Sequence Variability.

International journal of molecular sciences - 5 Jun 2026

Shchemelev Alexandr N, Serikova Elena N, Ostankova Yulia V, Davydenko Vladimir S, Ramsay Edward S, Totolian Areg A

Abstract excerpt

The extraordinary genetic diversity of human immunodeficiency virus type 1 (HIV-1), driven by high mutation and recombination rates, poses significant challenges for diagnostics, therapy, and vaccine development. While variable regions enable immune escape, hyperconserved regions are critical for viral function and represent promising targets for novel therapeutic interventions. This study aimed to develop and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42278661
DOI: 10.3390/ijms27115139
PMCID: PMC13257677

Genes

F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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