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Article

Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure.

AIDS (London, England) - 20 Aug 2004

Ceccherini-Silberstein Francesca, Erba Fulvio, Gago Federico, Bertoli Ada, Forbici Federica, Bellocchi Maria Concetta, Gori Caterina, D'Arrigo Roberta, Marcon Luisa, Balotta Claudia, Antinori Andrea, Monforte Antonella D'Arminio, Perno Carlo-Federico

Abstract excerpt

OBJECTIVE: To define the extent of amino acid protease (PR) conservation in vivo in the absence and presence of pharmacological pressure in a large patient cohort. METHODS: Plasma-derived complete protein PR sequences from a well-defined cohort of 1096 HIV-1 infected individuals (457 drug-naive and 639 under antiretroviral therapy including PR-inhibitors) were obtained and analysed, and are discussed in a...

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PMID: 15280771
DOI: 10.1097/01.aids.0000131394.76221.02

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