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Article

Effect of structural stress on the flexibility and adaptability of HIV-1 protease.

Journal of chemical information and modeling - 23 May 2011

Oehme Daniel P, Wilson David J D, Brownlee Robert T C

Abstract excerpt

Resistance remains a major issue with regards to HIV-1 protease, despite the availability of numerous HIV-1 protease inhibitors and copious amounts of structural and binding data. In an effort to improve our understanding of how HIV-1 protease is able to "outsmart" new drugs, we have investigated the flexibility of HIV-1 protease and in particular how it adapts to different structural stresses. Our analysis has...

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Source

Identifiers

PMID: 21500830
DOI: 10.1021/ci2000677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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