Article
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.
Journal of virology - 1 Aug 2005
Ceccherini-Silberstein Francesca, Gago Federico, Santoro Maria, Gori Caterina, Svicher Valentina, Rodríguez-Barrios Fátima, d'Arrigo Roberta, Ciccozzi Massimo, Bertoli Ada, d'Arminio Monforte Antonella, Balzarini Jan, Antinori Andrea, Perno Carlo-Federico
Abstract excerpt
To define the extent of sequence conservation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in vivo, the first 320 amino acids of RT obtained from 2,236 plasma-derived samples from a well-defined cohort of 1,704 HIV-1-infected individuals (457 drug naïve and 1,247 drug treated) were analyzed and examined in structural terms. In naïve patients, 233 out of these 320 residues (73%) were...
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