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Article

Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.

Journal of the neurological sciences - 15 Oct 2016

Zhang Youwen, Feng Shujun, Nie Kun, Zhao Xin, Gan Rong, Wang Limin, Zhao Jiehao, Tang Hongmei, Gao Liang, Zhu Ruiming, Wang Lijuan, Zhang Yuhu

Abstract excerpt

OBJECTIVE: The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of Parkinson's disease (PD) and have a specific impact on dopamine-mediated prefrontal executive function in an inverted-U curve manner. We explored the influence of this genetic polymorphism on prefrontal executive function in a well-established Chinese cohort of early PD patients with...

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Source

Identifiers

PMID: 27653922
DOI: 10.1016/j.jns.2016.08.063

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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