Article
Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta.
Oncogene - 29 Apr 1999
Canitrot Y, Lautier D, Laurent G, Fréchet M, Ahmed A, Turhan A G, Salles B, Cazaux C, Hoffmann J S
Abstract excerpt
Chronic myelogenous leukemia (CML) is characterized by the Philadelphia chromosome resulting from the translocation t(9-22) producing the chimeric 190 and 210 kDa BCR-ABL fusion proteins. Evolution of the CML to the more agressive acute myelogenous leukemia (AML) is accompanied by increased cellular proliferation and genomic instability at the cytogenetic level. We hypothezised that genomic instability at the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.