Article
Effect of human cell malignancy on activity of DNA polymerase iota.
Biochemistry. Biokhimiia - 1 Jul 2010
Kazakov A A, Grishina E E, Tarantul V Z, Gening L V
Abstract excerpt
An increased level of mutagenesis, partially caused by imbalanced activities of error prone DNA polymerases, is a key symptom of cell malignancy. To clarify the possible role of incorrect DNA polymerase iota (Pol iota) function in increased frequency of mutations in mammalian cells, the activity of this enzyme in extracts of cells of different mouse organs and human eye (melanoma) and eyelid (basal-cell skin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.