Comparison of Moloney murine leukemia virus mutation rate with the fidelity of its reverse transcriptase in vitro.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Comparison of Moloney murine leukemia virus mutation rate with the fidelity of its reverse transcriptase in vitro.

The Journal of biological chemistry - 5 Dec 1992

Varela-Echavarría A, Garvey N, Preston B D, Dougherty J P

Abstract excerpt

The role of Moloney murine leukemia virus (MoMLV) reverse transcriptase (RT) in the generation of base substitution mutations during retroviral replication was analyzed. To that effect, the in vitro fidelity of the MoMLV RT was compared to the rate of base substitution mutations occurring during...

Topics

3T3 Cells
Animals
Base Sequence
Blotting, Southern
Codon
DNA, Viral
Genetic Vectors
Kinetics
Mice
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Plasmids
Proviruses
RNA-Directed DNA Polymerase
Restriction Mapping
Transfection
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 1280265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1280265-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics