Article
Albuminuria is associated with too few glomeruli and too much testosterone.
Kidney international - 1 Jun 2013
Long David A, Kolatsi-Joannou Maria, Price Karen L, Dessapt-Baradez Cecile, Huang Jennifer L, Papakrivopoulou Eugenia, Hubank Mike, Korstanje Ron, Gnudi Luigi, Woolf Adrian S
Abstract excerpt
Normally, the glomerular filtration barrier almost completely excludes circulating albumin from entering the urine. Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans. Here we determine whether glomerular gene expression in mouse strains with naturally occurring variations in albuminuria would allow identification of proteins deregulated in relatively 'leaky'...
Topics
- Albuminuria
- Animals
- Blood Pressure
- Cells, Cultured
- Female
- Gene Expression Profiling
- Gene Expression Regulation
- Genotype
- Glomerular Filtration Barrier
- Kidney Glomerulus