Article
Unmasking of proteinuria in the course of genetic dissection of nonproteinuric diabetic nephropathy.
Physiological genomics - 1 Jan 2014
Yagil Yoram, Roif Diana, Sapojnikov Marina, Ben-Dor David, Tobar Ana, Rosenmann Eliezer, Yagil Chana
Abstract excerpt
We previously described the development of nonproteinuric diabetic nephropathy (NPDN) in the Cohen diabetic rat (CDs), a model that simulates Type 2 diabetes in humans. Using linkage analysis in an F2 cross, we currently set out to investigate the mechanisms underlying NPDN. We crossbred between CDs and SBN/y, a nondiabetic rat strain, generated F1 and F2 progenies, fed them diabetogenic diet that elicits...
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