Article
The neuropathological phenotype in transgenic mice expressing different prion protein constructs.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994
DeArmond S J, Yang S L, Cayetano-Canlas J, Groth D, Prusiner S B
Abstract excerpt
Neuropathologic examination of transgenic (Tg) mice which express different prion protein (PrP) constructs is essential because spongiform (vacuolar) degeneration of neurons, the distribution of PrPSc and whether PrP amyloid plaques form are the phenotypes of prion diseases. In Tg models of exper...
Topics
- Age Factors
- Animals
- Brain
- Creutzfeldt-Jakob Syndrome
- Disease Models, Animal
- Humans
- Mice
- Mice, Transgenic
- Phenotype
- PrPSc Proteins
- Prion Diseases
- Prions
- Scrapie