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Article

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism

30 Oct 2008

Abstract excerpt

While neuropathological features that define prion strains include spongiform degeneration and deposition patterns of PrP(Sc), the underlying mechanism for the strain-specific differences in PrP(Sc) targeting is not known. To investigate prion strain targeting, we inoculated hamsters in the sciatic nerve with either the hyper (HY) or drowsy (DY) strain of the transmissible mink encephalopathy (TME) agent. Both...

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PMID: 18971281
DOI: 10.1128/jvi.01745-08

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