Article
The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C.
Gastroenterology - 1 Jun 2000
McKiernan S M, Hagan R, Curry M, McDonald G S, Nolan N, Crowley J, Hegarty J, Lawlor E, Kelleher D
Abstract excerpt
BACKGROUND & AIMS: In hepatitis C infection, several studies have examined the role of the major histocompatibility complex (MHC) in determining outcome, with variable results. To clarify the importance of MHC, we examined class II DR and DQ antigens in a homogenous cohort of women exposed to hepatitis C genotype 1b from a single inoculum. METHODS: Of 243 participants, 95 had spontaneous viral clearance and 148...
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