Article
Genome-wide strategies for detecting multiple loci that influence complex diseases.
Nature genetics - 1 Apr 2005
Marchini Jonathan, Donnelly Peter, Cardon Lon R
Abstract excerpt
After nearly 10 years of intense academic and commercial research effort, large genome-wide association studies for common complex diseases are now imminent. Although these conditions involve a complex relationship between genotype and phenotype, including interactions between unlinked loci, the prevailing strategies for analysis of such studies focus on the locus-by-locus paradigm. Here we consider analytical...
Topics
- Alleles
- Genetic Diseases, Inborn
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genetics, Population
- Genome, Human
- Humans
- Models, Genetic