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Article

Molecular Evolution of the <i>Helicobacter pylori</i> Vacuolating Toxin Gene <i>vacA</i>

25 Sept 2010

Abstract excerpt

Helicobacter pylori is a genetically diverse organism that is adapted for colonization of the human stomach. All strains contain a gene encoding a secreted, pore-forming toxin known as VacA. Genetic variation at this locus could be under strong selection as H. pylori adapts to the host immune response, colonizes new human hosts, or inhabits different host environments. Here, we analyze the molecular evolution of...

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PMID: 20870762
DOI: 10.1128/jb.01081-10

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