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New genotypes of Helicobacter Pylori VacA d-region identified from global strains.

BMC molecular and cell biology - 7 Jan 2021

Soyfoo Djaleel Muhammad, Doomah Yussriya Hanaa, Xu Dong, Zhang Chao, Sang Huai-Ming, Liu Yan-Yan, Zhang Guo-Xin, Jiang Jian-Xia, Xu Shun-Fu

Abstract excerpt

BACKGROUND: Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct allelic diversity. The s-region, m-region and the c-region (a 15 bp deletion at the 3'-end region of the p55 domain of the vacA gene) exist as 2 types (s1, s2, m1, m2, c1 and c2), while the...

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PMID: 33413074
DOI: 10.1186/s12860-020-00338-2
PMCID: PMC7791883

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