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Genetic analysis of the <i>Helicobacter pylori</i> vacuoiating cytotoxin: structural similarities with the IgA protease type of exported protein

1 Apr 1994

Abstract excerpt

The human gastric bacterial pathogen Helicobacter pylori has been implicated in type B gastritis, peptic ulceration and gastric adenocarcinoma. Here we report on the cloning and genetic characterization of an H. pylori gene named vacA, which encodes the vacuolating cytotoxin VacA, a novel type of antigenic bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells. The vacuolating...

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PMID: 8057855
DOI: 10.1111/j.1365-2958.1994.tb01019.x

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