Article
Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma.
PLoS pathogens - 26 Aug 2010
Laude Hélène C, Jonchère Barbara, Maubec Eve, Carlotti Agnès, Marinho Eduardo, Couturaud Benoit, Peter Martine, Sastre-Garau Xavier, Avril Marie-Françoise, Dupin Nicolas, Rozenberg Flore
Abstract excerpt
Merkel Cell Polyomavirus (MCPyV) is associated with Merkel Cell carcinoma (MCC), a rare, aggressive skin cancer with neuroendocrine features. The causal role of MCPyV is highly suggested by monoclonal integration of its genome and expression of the viral large T (LT) antigen in MCC cells. We investigated and characterized MCPyV molecular features in MCC, respiratory, urine and blood samples from 33 patients by...
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