Virus-positive Merkel Cell Carcinoma Is an Independent Prognostic Group with Distinct Predictive Biomarkers.

doi:10.1158/1078-0432.CCR-20-0864

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Virus-positive Merkel Cell Carcinoma Is an Independent Prognostic Group with Distinct Predictive Biomarkers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2021

Harms Kelly L, Zhao Lili, Johnson Bryan, Wang Xiaoming, Carskadon Shannon, Palanisamy Nallasivam, Rhodes Daniel R, Mannan Rahul, Vo Josh N, Choi Jae Eun, Chan May P, Fullen Douglas R, Patel Rajiv M, Siddiqui Javed, Ma Vincent T, Hrycaj Steven, McLean Scott A, Hughes Tasha M, Bichakjian Christopher K, Tomlins Scott A, Harms Paul W

Abstract excerpt

PURPOSE: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that can be divided into two classes: virus-positive (VP) MCC, associated with oncogenic Merkel cell polyomavirus (MCPyV); and virus-negative (VN) MCC, associated with photodamage. EXPERIMENTAL DESIGN: We classified 346 MCC tumors from 300 patients for MCPyV using a combination of IHC, ISH, and qPCR assays. In a subset of...

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PMID: 33547200
DOI: 10.1158/1078-0432.CCR-20-0864
PMCID: PMC8995051

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