Article
The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment.
PloS one - 1 Jan 2020
Mendoza María-Dolores, Santonja Carlos, Gonzalez-Vela Carmen, Concha Angel, Iglesias Pena Nicolás, Andrés-Esteban Eva-Maria, Vaque Jose Pedro, Cereceda Laura, Pajares Raquel, Kutzner H, Requena Luis, Piris Miguel A
Abstract excerpt
AIMS: Merkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection. The presence of MCPyV defines heterogeneity in MCC; MCPyV-negative cases bear a much higher mutational load, with a distinct ultraviolet signature pattern featuring C > T transitions, as...
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