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Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome

29 Dec 2009

Abstract excerpt

MCPyV, a new human oncogenic polyoma virus, appears etiologic for the classic, rare, aggressive Merkel Cell Carcinomas (MCC) of the skin characterized by MCPyV DNA integration, high virus copy numbers,1 expression of the potentially transforming MCPyV large T antigen (LTA) evidenced by reactivity to monoclonal antibody CM2B4,2-4 signature mutations in LTA,5 expression of retinoblastoma protein3, 6 and a vigorous...

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PMID: 20041469
DOI: 10.1002/ijc.25136

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