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Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression

23 Jun 2009

Abstract excerpt

Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells. To investigate this heterogeneity, we developed a tissue microarray (TMA) to characterize immunohistochemical staining of candidate tumor cell proteins and a quantitative PCR assay to detect MCPyV and measure viral loads. MCPyV was...

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PMID: 19551862
DOI: 10.1002/ijc.24676

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