Article
Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Oct 2009
Stoller Douglas, Pytel Peter, Katz Sophie, Earley Judy U, Collins Keith, Metcalfe Jamie, Lang Roberto M, McNally Elizabeth M
Abstract excerpt
By sensing intracellular energy levels, ATP-sensitive potassium (K(ATP)) channels help regulate vascular tone, glucose metabolism, and cardioprotection. SUR2 mutant mice lack full-length K(ATP) channels in striated and smooth muscle and display a complex phenotype of hypertension and coronary vasospasm. SUR2 mutant mice also display baseline cardioprotection and can withstand acute sympathetic stress better than...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.