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Article

Paraffin-embedded tissue is less accurate than frozen section analysis for determining VHL mutational status in sporadic renal cell carcinoma.

Urologic oncology - 1 Jan 2000

Verhoest Grégory, Patard Jean-Jacques, Fergelot Patricia, Jouan Florence, Zerrouki Salim, Dreano Stéphane, Mottier Stéphanie, Rioux-Leclercq Nathalie, Denis Marc G

Abstract excerpt

INTRODUCTION: Literature controversies exist regarding the prognostic value of VHL mutations. The objective was to compare paraffin-embedded and frozen section specimens for VHL mutations detection and to evaluate the reliability of DNA analysis in formalin-fixed tissues. METHODS: Seventy-six patients with clear cell renal cell carcinoma (RCC) previously assessed for VHL status from frozen samples were included....

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Share to Carcinoma, Renal Cell
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Electrophoresis, Agar Gel

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 20863722
DOI: 10.1016/j.urolonc.2010.07.005

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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