Article
Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 1996
Zhuang Z, Gnarra J R, Dudley C F, Zbar B, Linehan W M, Lubensky I A
Abstract excerpt
The von Hippel-Lindau (VHL) disease gene on chromosome 3p25.5 has been cloned and shown to be mutated in the germline DNA of patients with VHL disease. In addition, approximately 60% of sporadic renal cell carcinomas (RCCs) have been shown to have a VHL gene mutation in fresh frozen tumor tissue...
Topics
- Adenoma, Oxyphilic
- Carcinoma, Renal Cell
- DNA
- DNA Mutational Analysis
- Humans
- Kidney
- Kidney Neoplasms
- Mutation
- Paraffin Embedding
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- von Hippel-Lindau Disease