Article
Sequencing of the von Hippel-Lindau gene in canine renal carcinoma.
Journal of veterinary internal medicine - 1 Jan 2000
Pressler B M, Williams L E, Ramos-Vara J A, Anderson K I
Abstract excerpt
BACKGROUND: Similarities in human and canine renal cell carcinoma (RCC) epidemiology and biologic behavior suggest that molecular mechanisms of tumorigenesis may be similar in both species. Approximately 75% of RCC in people are of the clear cell subtype, up to 85% of which are associated with mutation of the von Hippel-Lindau (VHL) gene. The canine VHL coding deoxyribonucleic acid (DNA) shares 90% identity with...
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