Article
VHL protein alterations in sporadic renal cell carcinoma.
Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Dec 2007
Giménez-Bachs J M, Salinas-Sánchez A S, Sánchez-Sánchez F, Lorenzo-Romero J G, Donate-Moreno M J, Pastor-Navarro H, Carrión-López P, Escribano-Martínez J, Virseda-Rodríguez J A
Abstract excerpt
AIMS: The vhl gene is a tumour suppressor gene implicated in renal tumorigenesis in both familial and sporadic renal cell carcinoma (RCC). Alterations in the gene may modify its suppressor function and allow the formation of renal tumours. The purpose of this study was to determine the existence of vhl gene mutations in renal tumour tissue among patients with sporadic RCC and to assess the effects on the...
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