Article
Needle core biopsies provide ample material for genomic and proteomic studies of kidney cancer: observations on DNA, RNA, protein extractions and VHL mutation detection.
Pathology, research and practice - 15 Jan 2012
Kurban Ghada, Gallie Brenda L, Leveridge Michael, Evans Andrew, Rushlow Diane, Matevski Donco, Gupta Rashi, Finelli Antonio, Jewett Michael A S
Abstract excerpt
The use of needle biopsies in basic research is increasing, and our study provides a comprehensive analysis of their adequacy in genomic and proteomic studies of kidney cancer. Frozen clear cell renal cell carcinoma (ccRCC) needle core biopsies and sections from core biopsies embedded in optimal cutting temperature (OCT) compound were used to extract DNA, RNA and protein. Their integrity was determined using...
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