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Article

Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.

Statistics in medicine - 10 Dec 2010

Crossett Andrew, Kent Brian P, Klei Lambertus, Ringquist Steven, Trucco Massimo, Roeder Kathryn, Devlin Bernie

Abstract excerpt

We propose a method to analyze family-based samples together with unrelated cases and controls. The method builds on the idea of matched case-control analysis using conditional logistic regression (CLR). For each trio within the family, a case (the proband) and matched pseudo-controls are constructed, based upon the transmitted and untransmitted alleles. Unrelated controls, matched by genetic ancestry, supplement...

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Identifiers

PMID: 20862653
DOI: 10.1002/sim.4057
PMCID: PMC4629477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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