Article
Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.
PloS one - 1 Jan 2013
Blanco Ana, de la Hoya Miguel, Osorio Ana, Diez Orland, Miramar María Dolores, Infante Mar, Martinez-Bouzas Cristina, Torres Asunción, Lasa Adriana, Llort Gemma, Brunet Joan, Graña Begoña, Perez Segura Pedro, Garcia María José, Gutiérrez-Enríquez Sara, Carracedo Ángel, Tejada María-Isabel, Velasco Eladio A, Calvo María-Teresa, Balmaña Judith, Benitez Javier, Caldés Trinidad, Vega Ana
Abstract excerpt
BACKGROUND: The PALB2 gene, also known as FANCN, forms a bond and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer and 3-4% of familial pancreatic cancer. The goal of this study was to determine the prevalence of PALB2 mutations in a population of BRCA1/BRCA2 negative breast cancer patients selected from either a personal or...
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