Article
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2010
Sun Yihua, Ren Yan, Fang Zhaoyuan, Li Chenguang, Fang Rong, Gao Bin, Han Xiangkun, Tian Weidong, Pao William, Chen Haiquan, Ji Hongbin
Abstract excerpt
PURPOSE: To determine the proportion of lung adenocarcinomas from East Asian never-smokers who harbor known oncogenic driver mutations. PATIENTS AND METHODS: In this surgical series, 52 resected lung adenocarcinomas from never-smokers (< 100 cigarettes in a lifetime) at a single institution (Fudan University, Shanghai, China) were analyzed concurrently for mutations in EGFR, KRAS, NRAS, HRAS, HER2, BRAF, ALK,...
Topics
- Adenocarcinoma
- Adult
- Aged
- Asian People
- Chi-Square Distribution
- China
- Class I Phosphatidylinositol 3-Kinases
- DNA Mutational Analysis
- ErbB Receptors
- Female