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Article

Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2010

Sun Yihua, Ren Yan, Fang Zhaoyuan, Li Chenguang, Fang Rong, Gao Bin, Han Xiangkun, Tian Weidong, Pao William, Chen Haiquan, Ji Hongbin

Abstract excerpt

PURPOSE: To determine the proportion of lung adenocarcinomas from East Asian never-smokers who harbor known oncogenic driver mutations. PATIENTS AND METHODS: In this surgical series, 52 resected lung adenocarcinomas from never-smokers (< 100 cigarettes in a lifetime) at a single institution (Fudan University, Shanghai, China) were analyzed concurrently for mutations in EGFR, KRAS, NRAS, HRAS, HER2, BRAF, ALK,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20855837
DOI: 10.1200/JCO.2010.29.6038
PMCID: PMC2974342

Genes

EGFR
ALK
BRAF
HRAS
KRAS
NRAS
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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