Article
Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR.
Oncotarget - 10 Mar 2015
Ha Sang Yun, Choi So-Jung, Cho Jong Ho, Choi Hye Joo, Lee Jinseon, Jung Kyungsoo, Irwin Darry, Liu Xiao, Lira Maruja E, Mao Mao, Kim Hong Kwan, Choi Yong Soo, Shim Young Mog, Park Woong Yang, Choi Yoon-La, Kim Jhingook
Abstract excerpt
The aim of this study was to determine the distribution of known oncogenic driver mutations in female never-smoker Asian patients with lung adenocarcinoma. We analyzed 214 mutations across 26 lung cancer-associated genes and three fusion genes using the MassARRAY LungCarta Panel and the ALK, ROS1, and RET fusion assays in 198 consecutively resected lung adenocarcinomas from never-smoker females at a single...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Asian People
- Case-Control Studies
- ErbB Receptors
- Female
- Follow-Up Studies
- Humans
- Lung Neoplasms