Article
Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2012
Zhang Yang, Sun Yihua, Pan Yunjian, Li Chenguang, Shen Lei, Li Yuan, Luo Xiaoyang, Ye Ting, Wang Rui, Hu Haichuan, Li Hang, Wang Lei, Pao William, Chen Haiquan
Abstract excerpt
PURPOSE: Our previous study revealed that 90% [47 of 52; 95% confidence interval (CI), 0.79-0.96] of Chinese never-smokers with lung adenocarcinoma harbor known oncogenic driver mutations in just four genes EGFR, ALK, HER2, and KRAS. Here, we examined the status of known driver mutations specific...
Topics
- Adenocarcinoma
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Anaplastic Lymphoma Kinase
- DNA Mutational Analysis
- ErbB Receptors
- Female
- Gene Frequency
- Genotype
- Humans
- Logistic Models
- Lung Neoplasms