Article
Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2018
Tessema Mathewos, Rossi Michael R, Picchi Maria A, Yingling Christin M, Lin Yong, Ramalingam Suresh S, Belinsky Steven A
Abstract excerpt
OBJECTIVES: Lung adenocarcinoma in never-smokers accounts for 15-20% of all lung cancer. Although targetable mutations are more prevalent in these tumors, the biological and clinical importance of coexisting and/or mutually exclusive abnormalities is just emerging. This study evaluates the relationships between common genetic and epigenetic aberrations in these tumors. MATERIALS AND METHODS: Next-generation...
Topics
- Adenocarcinoma of Lung
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Biomarkers, Tumor
- DNA Methylation
- Epigenesis, Genetic
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged