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Article

Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2018

Tessema Mathewos, Rossi Michael R, Picchi Maria A, Yingling Christin M, Lin Yong, Ramalingam Suresh S, Belinsky Steven A

Abstract excerpt

OBJECTIVES: Lung adenocarcinoma in never-smokers accounts for 15-20% of all lung cancer. Although targetable mutations are more prevalent in these tumors, the biological and clinical importance of coexisting and/or mutually exclusive abnormalities is just emerging. This study evaluates the relationships between common genetic and epigenetic aberrations in these tumors. MATERIALS AND METHODS: Next-generation...

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Share to Adenocarcinoma of Lung
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

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Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 30089603
DOI: 10.1016/j.lungcan.2018.07.011
PMCID: PMC6331003

Genes

EGFR
SETD2
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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