Article
Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder.
Neuroscience letters - 17 Dec 2010
Song Wenjia, Li Wenyan, Noltner Katie, Yan Jin, Green Elaine, Grozeva Detelina, Jones Ian R, Craddock Nick, Longmate Jeff, Feng Jinong, Sommer Steve S
Abstract excerpt
In a large Scottish pedigree, a balanced translocation t (1;11)(q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and depression. A frame-shift carboxyl-terminal deletion was reported in DISC1 in an American family with schizophrenia, but subsequently found in two controls. Herein, we test one hypothesis utilizing a large scale case-control mutation...
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