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Article

Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia.

Genes, brain, and behavior - 1 Oct 2012

Debono R, Topless R, Markie D, Black M A, Merriman T R

Abstract excerpt

The Disrupted-in-Schizophrenia 1 (DISC1) locus on human chromosome 1 was identified as a consequence of its involvement in a balanced translocation (1;11)(q42.1;q14.3) segregating with major psychiatric disorders in a Scottish family. Recently a comprehensive meta-analysis of genome-wide association scan data found no evidence that common variants of DISC1 (1q42.1) are associated with schizophrenia. Our aim was...

Topics

Case-Control Studies
Chromosomes, Human, Pair 11
Female
Genome-Wide Association Study
Humans
Male
Nerve Tissue Proteins
Polymorphism, Single Nucleotide
Risk Factors
Schizophrenia
Translocation, Genetic

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Identifiers

PMID: 22891933
DOI: 10.1111/j.1601-183X.2012.00832.x
PMCID: PMC5641267

Genes

DISC1

Provenance

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