Article
DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders.
Molecular psychiatry - 1 Dec 2018
Ryan Niamh M, Lihm Jayon, Kramer Melissa, McCarthy Shane, Morris Stewart W, Arnau-Soler Aleix, Davies Gail, Duff Barbara, Ghiban Elena, Hayward Caroline, Deary Ian J, Blackwood Douglas H R, Lawrie Stephen M, McIntosh Andrew M, Evans Kathryn L, Porteous David J, McCombie W Richard, Thomson Pippa A
Abstract excerpt
Psychiatric disorders are a group of genetically related diseases with highly polygenic architectures. Genome-wide association analyses have made substantial progress towards understanding the genetic architecture of these disorders. More recently, exome- and whole-genome sequencing of cases and families have identified rare, high penetrant variants that provide direct functional insight. There remains, however,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.