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Article

Functional characterization of CYP2C8.13 and CYP2C8.14: catalytic activities toward paclitaxel.

Basic & clinical pharmacology & toxicology - 1 Jul 2010

Hanioka Nobumitsu, Matsumoto Kimiaki, Saito Yoshiro, Narimatsu Shizuo

Abstract excerpt

Cytochrome P450 2C8 (CYP2C8) plays important roles in the metabolism of various drugs, including the anti-cancer drug, paclitaxel. We recently identified two novel CYP2C8 alleles (CYP2C8*13 and CYP2C8*14; wild-type, CYP2C8*1A) with non-synonymous single nucleotide polymorphisms in a Japanese population. To precisely investigate the effect of amino acid substitutions (CYP2C8*13, Ile223Met; CYP2C8*14, Ala238Pro) on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20148860
DOI: 10.1111/j.1742-7843.2010.00543.x

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