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Article

Effect of common exon variant (p.P364L) on drug glucuronidation by the human UDP-glucuronosyltransferase 1 family.

Basic & clinical pharmacology & toxicology - 1 Dec 2011

Mimura Yu, Maruo Yoshihiro, Ohta Yoriko, Sato Hiroshi, Takeuchi Yoshihiro

Abstract excerpt

The UDP-glucuronosyltransferases (UGTs) comprise a major excretion pathway for diverse endogenous and exogenous substrates. Relations are reported between polymorphisms of exon 1 of UGT1 and drug side effects or carcinogenesis, but few studies exist of common exon polymorphisms that exert influence throughout UGT1 isoforms. We analysed the polymorphism c.1091C>T, resulting in the amino acid substitution of...

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PMID: 21726413
DOI: 10.1111/j.1742-7843.2011.00754.x

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