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Article

Fibrogenic cell phenotype modifications during remodelling of normal and pathological human liver in cultured slices.

Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2010

Guyot Christelle, Lepreux Sébastien, Combe Chantal, Sarrazy Vincent, Billet Fabrice, Balabaud Charles, Bioulac-Sage Paulette, Desmoulière Alexis

Abstract excerpt

BACKGROUND: The debate concerning the potential remodelling and/or reversibility of cirrhotic lesions and biliary fibrosis is still open. AIMS/METHODS: In this work, we have used the precision-cut liver slice (PCLS) model, which maintains cell-cell and cell-matrix interactions to study, by immunohistochemistry, the behaviour of the different fibrogenic cells, i.e. hepatic stellate cells (HSC) and portal...

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PMID: 20846345
DOI: 10.1111/j.1478-3231.2010.02342.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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