Article
Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2008
Svegliati-Baroni Gianluca, De Minicis Samuele, Marzioni Marco
Abstract excerpt
Hepatic fibrosis represents the wound-healing response process of the liver to chronic injury, independently from aetiology. Advanced liver fibrosis results in cirrhosis that can lead to liver failure, portal hypertension and hepatocellular carcinoma. Currently, no effective therapies are available for hepatic fibrosis. After the definition of hepatic stellate cells (HSCs) as the main liver extracellular...
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