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Article

Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.

Human genomics - 1 Dec 2009

Bigham Abigail W, Mao Xianyun, Mei Rui, Brutsaert Tom, Wilson Megan J, Julian Colleen Glyde, Parra Esteban J, Akey Joshua M, Moore Lorna G, Shriver Mark D

Abstract excerpt

High-altitude environments (>2,500 m) provide scientists with a natural laboratory to study the physiological and genetic effects of low ambient oxygen tension on human populations. One approach to understanding how life at high altitude has affected human metabolism is to survey genome-wide datasets for signatures of natural selection. In this work, we report on a study to identify selection-nominated candidate...

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Identifiers

PMID: 20038496
DOI: 10.1186/1479-7364-4-2-79
PMCID: PMC2857381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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