Article
Fifteen years of the Diversity Outbred mouse model: a review.
Mammalian genome : official journal of the International Mammalian Genome Society - 28 Jan 2026
Tatom Zachary, Miles Michael F, Palmer Abraham A
Abstract excerpt
Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15 years, the Diversity Outbred (DO) mice have existed as a powerful tool for mapping complex traits. With eight founder strains contributing to high levels of genetic diversity, heterozygosity, and large numbers of recombination events, DO...
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