Article
Subspecific origin and haplotype diversity in the laboratory mouse.
Nature genetics - 29 May 2011
Yang Hyuna, Wang Jeremy R, Didion John P, Buus Ryan J, Bell Timothy A, Welsh Catherine E, Bonhomme François, Yu Alex Hon-Tsen, Nachman Michael W, Pialek Jaroslav, Tucker Priscilla, Boursot Pierre, McMillan Leonard, Churchill Gary A, de Villena Fernando Pardo-Manuel
Abstract excerpt
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.