Article

Multiple laboratory mouse reference genomes define strain specific haplotypes and novel functional loci

2018-02-12

Abstract excerpt

The most commonly employed mammalian model organism is the laboratory mouse. A wide variety of genetically diverse inbred mouse strains, representing distinct physiological states, disease susceptibilities, and biological mechanisms have been developed over the last century. We report full length draft de novo genome assemblies for 16 of the most widely used inbred strains and reveal for the first time extensive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ad8177d-afcd-5e23-9fcd-ff585c64c593
DOI: 10.1101/235838

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple laboratory mouse reference genomes define strain specific haplotypes and novel functional lociDOI 10.1101/235838Read

The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.Semantic proximity Read

Whole-genome sequence of the C57L/J mouse inbred strain.Semantic proximity Read

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.Semantic proximity Read

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse modelsSemantic proximity Read

A Tandem Repeat Atlas for the Genome of Inbred Mouse Strains: A Genetic Variation ResourceSemantic proximity Read

Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation, and homozygous truncating mutationsSemantic proximity Read

Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains captures global and local expression variationSemantic proximity Read

Mouse protein coding diversity: What's left to discover?Semantic proximity Read

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.Semantic proximity Read

Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations.Semantic proximity Read

A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns.Semantic proximity Read

Characterization of a strain-specific CD-1 reference genome reveals potential inter- and intra-strain functional variability.Semantic proximity Read