Article
A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns.
Genome research - 1 Feb 2005
Zhang Jinghui, Hunter Kent W, Gandolph Michael, Rowe William L, Finney Richard P, Kelley Jenny M, Edmonson Michael, Buetow Kenneth H
Abstract excerpt
Understanding of the structure and the origin of genetic variation patterns in the laboratory inbred mouse provides insight into the utility of the mouse model for studying human complex diseases and strategies for disease gene mapping. In order to address this issue, we have constructed a multistrain, high-resolution haplotype map for the 99-Mb mouse Chromosome 16 using approximately 70,000 single nucleotide...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes
- Computational Biology
- DNA
- Genetic Variation
- Genome
- Genotype
- Haplotypes
- Mice
- Mice, Inbred C57BL
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA