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Article

The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task-switching.

Neuropsychologia - 1 Jul 2010

Colzato Lorenza S, Waszak Florian, Nieuwenhuis Sander, Posthuma Danielle, Hommel Bernhard

Abstract excerpt

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Recent evidence suggests that the Val158Met genotype may differentially affect cognitive stability and flexibility, in such a way that Val/Val homozygous individuals (who possess low prefrontal dopamine levels) may show more...

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Source

Identifiers

PMID: 20434465
DOI: 10.1016/j.neuropsychologia.2010.04.023

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task-switching.PMID 20434465Read ↗

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