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Article

COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia.

Pharmacopsychiatry - 1 Jul 2009

Neuhaus A H, Opgen-Rhein C, Urbanek C, Hahn E, Ta T M T, Seidelsohn M, Strathmann S, Kley F, Wieseke N, Sander T, Dettling M

Abstract excerpt

BACKGROUND: Associations between the well-known functional single nucleotide polymorphism Val (158)Met in the gene encoding catechol- O-methyltransferase (COMT) and cognitive do-mains affected in schizophrenia are inconsistent regarding directionality and specific impact and call for a more fundamental cognitive endophenotype. Recent studies suggest that the COMT genotype contributes to cognitive flexibility, a...

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Source

Identifiers

PMID: 19585392
DOI: 10.1055/s-0028-1112132

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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