Article
ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.
PloS one - 1 Jan 2012
Terao Chikashi, Ohmura Koichiro, Ikari Katsunori, Kochi Yuta, Maruya Etsuko, Katayama Masaki, Yurugi Kimiko, Shimada Kota, Murasawa Akira, Honjo Shigeru, Takasugi Kiyoshi, Matsuo Keitaro, Tajima Kazuo, Suzuki Akari, Yamamoto Kazuhiko, Momohara Shigeki, Yamanaka Hisashi, Yamada Ryo, Saji Hiroo, Matsuda Fumihiko, Mimori Tsuneyo
Abstract excerpt
HLA-DRB1, especially the shared epitope (SE), is strongly associated with rheumatoid arthritis (RA). However, recent studies have shown that SE is at most weakly associated with RA without anti-citrullinated peptide/protein antibody (ACPA). We have recently reported that ACPA-negative RA is associated with specific HLA-DRB1 alleles and diplotypes. Here, we attempted to detect genetically different subsets of...
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