Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology - 1 Dec 2009

Ohmura Koichiro

Abstract excerpt

These days, rheumatoid arthritis (RA) is reported to be subclassified into two subsets by anti-citrullinated peptide antibody (ACPA) positivity. Clinically, ACPA positive RA tends to develop more severe arthritis than ACPA negative RA. In addition, a lot of reported susceptibility genes to RA (ie. HLA-DRB1(*)04, PTPN22, TRAF1/C5, CTLA4) are found to be associated only with ACPA positive RA but not with ACPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Citrulline

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Peptides

Share to Risk Factors

Source

Identifiers

PMID: 20046016
DOI: 10.2177/jsci.32.484

Genes

CTLA4
PTPN22
STAT4
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?].PMID 20046016Read ↗

Is rheumatoid arthritis an autoimmune disease?Semantic proximity Read ↗

[Recent advances in the pathogenesis of rheumatoid arthritis].Semantic proximity Read ↗

HLA and anti-citrullinated protein antibodies: Building blocks in RA.Semantic proximity Read ↗

New insights into the genetics of immune responses in rheumatoid arthritis.Semantic proximity Read ↗

ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translationSemantic proximity Read ↗

The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritisSemantic proximity Read ↗

Immunity to Citrullinated Proteins in Rheumatoid ArthritisSemantic proximity Read ↗

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiologySemantic proximity Read ↗

[Rheumatoid arthritis pathogenesis. From susceptibility to autoimmunity, and arthritis].Semantic proximity Read ↗

[Basic research overview in rheumatoid arthritis].Semantic proximity Read ↗

ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.Semantic proximity Read ↗

Citrullinated peptide and its relevance to rheumatoid arthritis: an update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.